Research on Anti-inflammatory Targets and Mechanisms of alkaloids in Picrasma quassioides Benn Through Network Pharmacology

This study aimed to investigate the molecular mechanism of Picrasma quassioides Benn against inflammation by means network pharmacology. The paper will provide a reference for multi-target and multi-channel treatment with traditional Chinese medicine. Through screening analysis, 11 active ingredients 109 anti-inflammation prediction targets were obtained constructed compound-target network. such as VEGFA, TLR4 STAT3 may play crucial role. Network enrichment analysis showed that potential constitute number pathways or inflammatory reactions closely related inflammation, including NF-κB signaling pathway MAPK pathway. docking results indicated binding energy Picrasidine Y factors VEGFA is highest. predicted role multiple compounds in alkaloids response, provided theoretical basis anti-inflammatory Picrasma.